1-Methyl-2-nitro-3-(trifluoromethyl)benzene → 2-Amino-3-methylbenzotrifluoride

HRID 643135Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 643135
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:11])([F:10])[F:9])[C:3]=1[N+:12]([O-])=O.[H][H]>CO.[Pd]>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:9])([F:10])[F:11])[C:3]=1[NH2:12]

Komponenten

5

Edukt 2

HCID 134554311-Methyl-2-nitro-3-(trifluoromethyl)benzeneHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 133182332-Amino-3-methylbenzotrifluoride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of 50 g (0.24 mol) 1-methyl-2-nitro-3-trifluoromethyl-benzene and 4.4 g 10% Pd/C in 300 mL MeOH was hydrogenated at RT and 3000 hPa hydrogen pressure until the theoretical amount of hydrogen had been taken up. The catalyst was filtered off, washed with MeOH and the filtrate was evaporated down. The crude product was further reacted without purification.

Aufarbeitung

  1. customwas hydrogenated at RT
  2. filtrationThe catalyst was filtered off
  3. washwashed with MeOH
  4. customthe filtrate was evaporated down
  5. customThe crude product was further reacted without purification

Quellen und Nachweise

ORD-Eintrag
ord-c6dde853916841a48b1074fb71e1089e
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07696209B2

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