Acetic Anhydride → HCID 178475126, Verbindung

HRID 643978Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 643978
[CH3:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([CH:11]=[N:12][NH:13][C:14]([NH2:16])=[S:15])[CH:9]=2)[NH:4][N:3]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[C:17]([NH:16][C:14](=[N:13]/[N:12]=[CH:11]/[C:8]1[CH:9]=[C:10]2[C:2]([CH3:1])=[N:3][NH:4][C:5]2=[N:6][CH:7]=1)[SH:15])(=[O:19])[CH3:18]

Komponenten

3

Edukt 2

HCID 7918Acetic AnhydrideHCID 178434443HCID 178434443, Verbindung

Produkt 1

HCID 178475126HCID 178475126, Verbindung

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

The staring material 1-((3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methylene)thiosemicarbazide (500 mg, 2.0 mmol) and acetic anhydride (20 ml) was mixed and heated to 80° C. for 1 hour. The reaction mixture was then cooled down to room temperature. The yellow solid was precipitated out and was filtered off. The yellow solid was washed with ether (50 ml). The product was obtained in quantitative yield and used for the next step without further purification.

Aufarbeitung

  1. temperatureThe reaction mixture was then cooled down to room temperature
  2. customThe yellow solid was precipitated out and
  3. filtrationwas filtered off
  4. washThe yellow solid was washed with ether (50 ml)
  5. customThe product was obtained in quantitative yield
  6. customused for the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-a99e7aa7887b42d69f7cc87af2fc61fe
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07700636B2

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