Methanol → Methyl 4-isopropyl-2-methoxymethoxybenzoate

HRID 644211Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 644211
C(Cl)Cl.[CH:4]([C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[C:9]([O:16][CH2:17][O:18][CH3:19])[CH:8]=1)([CH3:6])[CH3:5].CO.[CH3:22][Si](C=[N+]=[N-])(C)C>CC(O)=O.CCCCCC>[CH:4]([C:7]1[CH:15]=[CH:14][C:10]([C:11]([O:13][CH3:22])=[O:12])=[C:9]([O:16][CH2:17][O:18][CH3:19])[CH:8]=1)([CH3:6])[CH3:5]

Komponenten

7

Edukt 4

HCID 887MethanolHCID 6344DichloromethaneHCID 167693TrimethylsilyldiazomethaneHCID 685322784-Isopropyl-2-methoxymethoxybenzoic acid

Produkt 1

HCID 68533886Methyl 4-isopropyl-2-methoxymethoxybenzoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 8058HexaneLösungsmittel

Versuchsvorschrift

Into methylene chloride (40 mL) was dissolved 4-isopropyl-2-methoxymethoxy-benzoic acid (6.0 g, 26.8 mmol). Methanol (10 mL) was added, followed by the dropwise addition of 2 M hexane solution of trimethylsilyldiazomethane (14.7 mL). After 2 h, HOAc (0.5 mL) was added and the solvent was removed under vacuum, giving the title compound as an oil, which was used in next step without further purification.

Aufarbeitung

  1. customthe solvent was removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-d11ef92e482541bb958da1018f73d6b8
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07700628B2

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