Dimethyl Sulfoxide → HCID 68537107, Verbindung

HRID 644268

Reaktionsgleichung

Reaktionsgleichung von HRID 644268
F[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([O:12][CH2:13][O:14][CH3:15])[CH:3]=1.CS(C)=O.[CH2:20]([S-:22])[CH3:21].[Na+]>O>[CH2:20]([S:22][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([O:12][CH2:13][O:14][CH3:15])[CH:3]=1)[CH3:21]

Komponenten

5

Edukt 3

HCID 679Dimethyl SulfoxideHCID 4459711Sodium ethanethiolateHCID 58437341Methyl 4-fluoro-2-(methoxymethoxy)benzoate

Produkt 1

HCID 68537107HCID 68537107, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of methyl 4-fluoro-2-(methoxymethoxy)benzoate (10.6 g, 50 mmol) and DMSO (20 mL), under nitrogen, was added sodium ethanethiolate (5.8 g, 55 mmol) in portions. The exothermic reaction was stirred for 19 h, diluted with water, and extracted with ethyl acetate. The organic layer was concentrated; and the residue was dissolved in ether, filtered through diatomaceus earth, and concentrated to give intermediate methyl 4-(ethylthio)-2-(methoxymethoxy)benzoate.

Aufarbeitung

  1. customThe exothermic reaction
  2. extractionextracted with ethyl acetate
  3. concentrationThe organic layer was concentrated
  4. dissolutionand the residue was dissolved in ether
  5. filtrationfiltered through diatomaceus earth
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-d0e303483cf64d2d85a34241994a09d2
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07700628B2

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