StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

Dimethylformamide → HCID 68579999, Verbindung

HRID 644306
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 644306
C(N(C(C)C)C(C)C)C.[NH2:10][CH:11]([CH2:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH3:24])=[C:19]([CH2:25][CH3:26])[CH:18]=1)[C:12]([O:14][CH3:15])=[O:13].[CH3:27][N:28]([CH:30]=[O:31])[CH3:29].N1C[CH2:36][CH:35]([N:38]2[CH2:47][C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[NH:40][C:39]2=[O:48])[CH2:34]C1>C1COCC1>[CH2:25]([C:19]1[CH:18]=[C:17]([CH2:16][CH:11]([NH:10][C:30]([N:28]2[CH2:29][CH2:34][CH:35]([N:38]3[CH2:47][C:46]4[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=4)[NH:40][C:39]3=[O:48])[CH2:36][CH2:27]2)=[O:31])[C:12]([O:14][CH3:15])=[O:13])[CH:22]=[CH:21][C:20]=1[CH2:23][CH3:24])[CH3:26]
KomponentenReaktionsbedingungenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 110425973-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-oneHCID 22184541HCID 22184541, Verbindung

Produkt 1

HCID 68579999HCID 68579999, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028
Tetrahydrofuran
Lösungsmittel

Reaktionsbedingungen

Temperatur
5 °C

Versuchsvorschrift

3.3 mL ethyldiisopropyl-amine and 2.06 g (12.6 mmol) of CDT were added to an ice-cooled solution of 2.95 g (12.54 mmol) of methyl 2-amino-3-(3,4-diethyl-phenyl)-propionate in 200 mL of THF and stirred for a further 90 min at 0-10° C. Then 20 mL of DMF were added, the mixture was stirred for a further 30 min, 2.91 g (12.6 mmol) of 3-piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one were added and the suspension was refluxed for 10 h. The reaction mixture was evaporated down in vacuo, combined with semisaturated NaHCO3 solution, exhaustively extracted with EtOAc and dried over MgSO4. After elimination of the desiccant and solvent the crude product was reacted without any further purification.

Aufarbeitung

  1. stirringthe mixture was stirred for a further 30 min
  2. temperaturethe suspension was refluxed for 10 h
  3. customThe reaction mixture was evaporated down in vacuo
  4. extractionexhaustively extracted with EtOAc
  5. dry with materialdried over MgSO4
  6. customAfter elimination of the desiccant and solvent the crude product was reacted without any further purification

Quellen und Nachweise

ORD-Eintrag
ord-f7c9205a25b9464ea8c0a7531cf56ab5
Quelldatensatz
uspto-grants-2010_04
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US07700589B2

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenReaktionsbedingungenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion