4-Azetidin-1-yl-1-benzyl-piperidine → 4-(Azetidin-1-YL)piperidine

HRID 644356Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 644356
[N:1]1([CH:5]2[CH2:10][CH2:9][N:8](CC3C=CC=CC=3)[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[H][H]>CO.[Pd]>[N:1]1([CH:5]2[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 2

HCID 231533994-Azetidin-1-yl-1-benzyl-piperidineHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 231531094-(Azetidin-1-YL)piperidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

3.2 g (13.9 mmol) 4-azetidin-1-yl-1-benzyl-piperidine dissolved in 50 mL MeOH were hydrogenated in the autoclave in the presence of 0.5 g Pd/C (10%) at 50° C. and 3 bar hydrogen pressure until the calculated volume of hydrogen had been taken up. The catalyst was filtered off and the solvent was eliminated under reduced pressure.

Aufarbeitung

  1. filtrationThe catalyst was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-a920274d7d824753a91b7afa7bd1fc4f
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07700589B2

Notizen zur Reaktion

Wird geladen…