Hydrazine hydrate (1:1) → 2-Phenyl-3-pyrrolidin-1-yl propylamine
Reaktionsgleichung
[C:1]1([CH:7]([CH2:20][N:21]2CCCC2)[CH2:8][N:9]2[C:17](=O)[C:16]3[C:11](=CC=CC=3)[C:10]2=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.NN>C(O)C>[C:1]1([CH:7]([CH2:8][N:9]2[CH2:17][CH2:16][CH2:11][CH2:10]2)[CH2:20][NH2:21])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of 2-(2-phenyl-3-pyrrolidin-1-yl propyl)isoindole-1,3-dione (3 mmol) and hydrazine monohydrate (6 mmol) in ethanol (10 mL) is refluxed for 3.5 h. The reaction mixture is cooled and filtered through celite. The filtrate is concentrated in vacuo to give the title compound, which is directly used for the next reaction without further purification.