Tetrahydrofuran → 2,4-Dichloro-5-pyrimidinecarboxylic acid

HRID 645509

Reaktionsgleichung

Reaktionsgleichung von HRID 645509
[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([C:9](Cl)=[O:10])=[CH:4][N:3]=1.C1C[O:15]CC1>O>[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([C:9]([OH:10])=[O:15])=[CH:4][N:3]=1

Komponenten

4

Edukt 2

HCID 8028TetrahydrofuranHCID 137841122,4-Dichloropyrimidine-5-carbonyl chloride

Produkt 1

HCID 219418962,4-Dichloro-5-pyrimidinecarboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

To a solution of the 2,4-dichloropyrimidine-5-carbonyl chloride (24 mmol) in THF (24 mL) is added H2O (0.64 mL) at room temperature. The reaction mixture is stirred at room temperature for 0.83 h and then diluted with H2O. The mixture is extracted with AcOEt. The organic extracts are washed with brine, dried over Na2SO4, filtered, and concentrated in vacuo to give the crude titled compound; 1H NMR (CDCl3) δ 6.80 (brs, 1H), 9.18 (s, 1H).

Aufarbeitung

  1. extractionThe mixture is extracted with AcOEt
  2. washThe organic extracts are washed with brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a6d60d2669694752a24f9d7362b9c7a5
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07704996B2

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