Benzyl mercaptan → 2-Benzylthio-4-(2-chloro-4-trifluoromethylphenoxy)nitrobenzene

HRID 64556

Reaktionsgleichung

Reaktionsgleichung von HRID 64556
[CH2:1]([SH:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].[Cl:11][C:12]1[CH:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:28]=[CH:27][C:13]=1[O:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[C:17]([N+]([O-])=O)[CH:16]=1>O1CCCC1>[CH2:1]([S:8][C:17]1[CH:16]=[C:15]([O:14][C:13]2[CH:27]=[CH:28][C:29]([C:31]([F:34])([F:32])[F:33])=[CH:30][C:12]=2[Cl:11])[CH:20]=[CH:19][C:18]=1[N+:21]([O-:23])=[O:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 7509Benzyl mercaptanHCID 24758Sodium hydrideHCID 156238Benzene, 2-chloro-1-(3,4-dinitrophenoxy)-4-(trifluoromethyl)-

Produkt 1

HCID 202362812-Benzylthio-4-(2-chloro-4-trifluoromethylphenoxy)nitrobenzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

1.7 g of benzyl mercaptan was dissolved in dry tetrahydrofuran and 0.5 g of sodium hydride added with stirring under dry nitrogen. The reaction mixture was stirred under reflux for 30 minutes, and a solution of 5 g of 1A dissolved in 25 ml of dry tetrahydrofuran was added dropwise. Reaction occurred rapidly, and the product was chromatographically purified to give 2-benzylthio-4-(2-chloro-4-trifluoromethylphenoxy)nitrobenzene (1B) as a yellow oil.

Aufarbeitung

  1. stirringThe reaction mixture was stirred
  2. temperatureunder reflux for 30 minutes
  3. additionwas added dropwise
  4. customReaction
  5. customthe product was chromatographically purified

Quellen und Nachweise

ORD-Eintrag
ord-a90262bdbc264b34851ba14fae0a069f
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04609394

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