Tert-Butylamine → N-(tert-Butyl)-2-(1-piperazinyl)acetamide dihydrochloride

HRID 645759

Reaktionsgleichung

C(OC(N1CCNCC1)=O)(C)(C)C.[Cl:14]CC(Cl)=O.[C:19]([NH2:23])([CH3:22])([CH3:21])[CH3:20].[ClH:24].Cl.COCC(N[C:32](=[O:40])[CH2:33][N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1)C>>[ClH:14].[ClH:24].[C:19]([NH:23][C:32](=[O:40])[CH2:33][N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1)([CH3:22])([CH3:21])[CH3:20]

Komponenten

Edukt 4

HCID 6385Tert-Butylamine

HCID 6577Chloroacetyl chloride

HCID 143452tert-Butyl piperazine-1-carboxylate

HCID 67245894N-(2-methoxy-1-methylethyl)-2-piperazin-1-yl-acetamide dihydrochloride

Produkt 1

HCID 16246646N-(tert-Butyl)-2-(1-piperazinyl)acetamide dihydrochloride

Versuchsvorschrift

N-tert-butyl-2-piperazin-1-yl-acetamide dihydrochloride was prepared from 1-tert-butyloxycarbonyl-piperazine, chloroacetylchloride and N-tert-butylamine in an analogous manner as described for the preparation of N-(2-methoxy-1-methyl-ethyl)-2-piperazin-1-yl-acetamide dihydrochloride (example 40).

Quellen und Nachweise

ORD-Eintrag: ord-a6ec88f12531480cba0c162d28297433
Quelldatensatz: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07705007B2

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