Dimethylformamide → HCID 70469256, Verbindung

HRID 64583

Reaktionsgleichung

Reaktionsgleichung von HRID 64583
[OH:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C:7]2[C:16](C)=[N:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)=[CH:4][CH:3]=1.[H-].[Na+].[H][H].Br[CH:25]([CH3:32])[CH:26]=[CH:27][C:28]([O:30][CH3:31])=[O:29].[CH3:33]N(C)C=O>O>[CH3:33][C:7]1([O:6][C:5]2[CH:4]=[CH:3][C:2]([O:1][CH:25]([CH3:32])[CH:26]=[CH:27][C:28]([O:30][CH3:31])=[O:29])=[CH:19][CH:18]=2)[N:8]=[C:9]2[C:14]([CH:13]=[CH:12][CH:11]=[CH:10]2)=[N:15][CH2:16]1

Komponenten

7

Edukt 5

HCID 6228Dimethylformamide2×HCID 24758Sodium hydrideHCID 136705382-(4-Hydroxyphenoxy)-3-methylquinoxalineHCID 54128087Methyl 4-bromo-2-pentenoateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 70469256HCID 70469256, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

In a nitrogen atmosphere, add a solution of 5.4 g (0.02 mole) 2-(4-hydroxyphenoxy)-3-methylquinoxaline in 30 cc dimethylformamide to 0.9 g (0.02 mole) 57% sodium hydride in 20 cc dimethylformamide at about 20° C. When the evolution of hydrogen ceases, add 3.9 g (0.02 mole) methyl 4-bromo-2-pentenoate. Heat the reaction mixture at approximately 80° C. until the reaction is complete. Pour the reaction mixture into water and extract with ether. Combine the ethereal extracts and dry over magnesium sulfate. Removal of the ether gives the desired product.

Aufarbeitung

  1. extractionextract with ether
  2. dry with materialdry over magnesium sulfate
  3. customRemoval of the ether

Quellen und Nachweise

ORD-Eintrag
ord-aa9f6b8071fc48d085f88192195dc687
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04609396

Verknüpfte Notizen

Wird geladen…