HCID 18449044, Verbindung → 4-(5-Difluoromethoxy-3-trifluoromethyl-pyrazol-1-yl)-benzaldehyde

HRID 645956Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 645956
[F:1][CH:2]([F:21])[O:3][C:4]1[N:8]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][OH:16])=[CH:11][CH:10]=2)[N:7]=[C:6]([C:17]([F:20])([F:19])[F:18])[CH:5]=1>C(Cl)Cl.O=[Mn]=O>[F:21][CH:2]([F:1])[O:3][C:4]1[N:8]([C:9]2[CH:10]=[CH:11][C:12]([CH:15]=[O:16])=[CH:13][CH:14]=2)[N:7]=[C:6]([C:17]([F:20])([F:19])[F:18])[CH:5]=1

Komponenten

4

Edukt 1

HCID 18449044HCID 18449044, Verbindung

Produkt 1

HCID 184490424-(5-Difluoromethoxy-3-trifluoromethyl-pyrazol-1-yl)-benzaldehydeAusbeute 95,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of [4-(5-difluoromethoxy-3-trifluoromethyl-pyrazol-1-yl)-phenyl]-methanol (380 mg, 1.2 mmol) in DCM (20 mL) was treated with excess amount of MnO2 was stirred at room temperature for 24 hours. The mixture was filtered and the filtrate was concentrated under reduced pressure. Purification by chromatography (SiO2, 6:1 hexane/EtOAc) gave 4-(5-difluoromethoxy-3-trifluoromethyl-pyrazol-1-yl)-benzaldehyde (350 mg, 93% yield) as a syrup.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customPurification by chromatography (SiO2, 6:1 hexane/EtOAc)

Quellen und Nachweise

ORD-Eintrag
ord-9ae11630f6454ecda731d98dd5ccfd55
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07705029B2

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