Triethylamine → 3-[(3-Nitro-2-pyrazinyl)amino]-1,2-propanediol

HRID 64610

Reaktionsgleichung

Reaktionsgleichung von HRID 64610
Cl[C:2]1[C:3]([N+:8]([O-:10])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.C(N(CC)CC)C.[NH2:18][CH2:19][CH:20]([OH:23])[CH2:21][OH:22]>C(O)(C)C>[OH:23][CH:20]([CH2:21][OH:22])[CH2:19][NH:18][C:2]1[C:3]([N+:8]([O-:10])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 735613-Amino-1,2-propanediolHCID 159142352-Chloro-3-nitropyrazine

Produkt 1

HCID 159142393-[(3-Nitro-2-pyrazinyl)amino]-1,2-propanediol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

To a solution of 1.5 g (0.0094 mol) 3 and 1.01 g (0.01 mol) triethylamine in 25 ml isopropanol is added 0.91 g (0.01 mol) 3-amino-1,2-propanediol (10). The reaction mixture becomes reddish and is stirred at room temperature for 16 hours. The solvent is then removed on the rotary evaporator and the residue is purified by flash chromatography on silica gel to afford pure 11 as a yellow solid, m.p. 100°-102°.

Aufarbeitung

  1. customThe solvent is then removed on the rotary evaporator
  2. customthe residue is purified by flash chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-823de0febb72478ca27925ee6def8ecd
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04609659

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