Sodium Methoxide → Sodium 5-(4-isopropoxyphenyl)-1-(2-naphthyl)indole-2-carboxylate

HRID 646114Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 646114
[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[N:16]([C:20]2[CH:29]=[CH:28][C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:21]=2)[C:15]([C:30]([OH:32])=[O:31])=[CH:14]3)=[CH:7][CH:6]=1)([CH3:3])[CH3:2].C[O-].[Na+:35]>C1COCC1>[CH:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[N:16]([C:20]2[CH:29]=[CH:28][C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:21]=2)[C:15]([C:30]([O-:32])=[O:31])=[CH:14]3)=[CH:9][CH:10]=1)([CH3:3])[CH3:2].[Na+:35]

Komponenten

4

Edukt 2

HCID 10942334Sodium MethoxideHCID 686968775-(4-Isopropoxyphenyl)-1-(2-naphthyl)indole-2-carboxylic acid

Produkt 1

HCID 68702464Sodium 5-(4-isopropoxyphenyl)-1-(2-naphthyl)indole-2-carboxylateAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

5-(4-Isopropoxyphenyl)-1-(2-naphthyl)indole-2-carboxylic acid (40 mg, 0.095 mmol; see Example 18) was dissolved in dry THF (1 mL) and NaOMe (3.37 M, 28 μL) was added via syringe. After stirring for 30 min at room temperature, the solvents were removed under reduced pressure and the residue dried in vacuo to yield the title compound (42 mg, 99%).

Aufarbeitung

  1. customthe solvents were removed under reduced pressure
  2. customthe residue dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-fec5dbf52c024ac3929f3149fc571cb6
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07705023B2

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