Water → 4-[(2,4-Dichlorophenyl)phenylmethyl]-1H-pyrazole

HRID 64633Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 64633
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH:16]([CH:19]=O)[CH:17]=O)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[NH2:21][NH2:22].O>C(O)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:16]1[CH:19]=[N:21][NH:22][CH:17]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 9321HydrazineHCID 54388185HCID 54388185, Verbindung

Produkt 1

HCID 136726874-[(2,4-Dichlorophenyl)phenylmethyl]-1H-pyrazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Two grams of [(2,4-dichlorophenyl)phenylmethyl]malonaldehyde in 10 ml of ethanol were heated with 3 ml of anhydrous hydrazine on a steam bath for two hours. The reaction mixture was poured into water and extracted with ether. The ether extract was dried, filtered, and evaporated. The residue was crystallized twice from Skelley B/acetone to provide 1.2 g of the desired title product, m.p. 131° C.

Aufarbeitung

  1. extractionextracted with ether
  2. extractionThe ether extract
  3. customwas dried
  4. filtrationfiltered
  5. customevaporated
  6. customThe residue was crystallized twice from Skelley B/acetone

Quellen und Nachweise

ORD-Eintrag
ord-cb337b6c2bb44925af26f18ccc8fd109
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04609666

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