Hydrochloric Acid → 1,3-Dibenzyloxy-2-chloromethoxypropane

HRID 64667

Reaktionsgleichung

[ClH:1].[CH2:2]([O:9][CH2:10][CH:11]([CH2:13][O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[OH:12])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:22]=O>ClCCCl>[CH2:2]([O:9][CH2:10][CH:11]([CH2:13][O:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[O:12][CH2:22][Cl:1])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Komponenten

Reaktionsbedingungen

Temperatur: 21 °C

Versuchsvorschrift

Dry hydrogen chloride gas was bubbled for 1.5 hours into a solution of 1,3-di-O-benzylglycerol from Preparation I (15 g, 55 mmol) and paraformaldehyde (3.3 g, 110 mmol) in 175 ml of 1,2-dichloroethane at 0° C. The solution was then stored in a stoppered flask for 21 hours at 4° C. Next, the solution was dried over magnesium sulfate with warming to 21° C. then filtered and concentrated to give 17.5 g of 1,3-di-O-benzyl-2-O-chloromethylglycerol.

Aufarbeitung

dry with materialNext, the solution was dried over magnesium sulfate
filtrationthen filtered
concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag: ord-195aba5c8cd1451ab07737cf1357ad07
Quelldatensatz: uspto-grants-1986_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04609661

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