3-(Trifluoromethyl)phenol → 2-Butanol, 4-chloro-1-[3-(trifluoromethyl)phenoxy]-

Temperatur

65 °C

To a mixture of 0.5 mole (75 g.) of m-trifluoromethylphenol, 1 mole (56 g.) of potassium hydroxide, 100 ml. of water and 400 ml. of isopropanol was added 0.6 mole (84 g.) of 1,4-dichloro-2-butanol with stirring at temperature below 55° C. The resulting reaction mixture was heated at 65° C. for 20 hr., mixed with 2 liters of water, and extracted with 400 ml. of isopropyl ether. The ether extract was washed with 0.5N sodium hydroxide and then with water, dried over sodium sulfate and distilled under reduced pressure. The distillate which was collected at 120°-124° C./0.01 mm. solidified at room temperature and melted at 50°-52° C.

1. customThe resulting reaction mixture
2. extractionextracted with 400 ml
3. extractionThe ether extract
4. washwas washed with 0.5N sodium hydroxide
5. dry with materialwith water, dried over sodium sulfate
6. distillationdistilled under reduced pressure
7. distillationThe distillate which was collected at 120°-124° C./0.01 mm
8. customsolidified at room temperature

ORD-Eintrag

ord-f451d76dd022479d86c4d6ad57a6b1ae

Quelldatensatz

uspto-grants-1986_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04609735