Dimethylamine → 1-(3-Trifluoromethylphenyl)-1,2,4-triazole

HRID 64766

Reaktionsgleichung

Reaktionsgleichung von HRID 64766
[CH3:1][NH2+:2][CH3:3].[F:4][C:5]([F:15])([F:14])[C:6]1[CH:7]=[C:8]([NH:12][NH2:13])[CH:9]=[CH:10][CH:11]=1.CNC>CCOCC>[F:4][C:5]([F:14])([F:15])[C:6]1[CH:7]=[C:8]([N:12]2[CH:3]=[N:2][CH:1]=[N:13]2)[CH:9]=[CH:10][CH:11]=1

Komponenten

5

Edukt 3

HCID 674DimethylamineHCID 98650(3-(Trifluoromethyl)phenyl)hydrazineHCID 3614769Dimethylaminium

Produkt 1

HCID 137142611-(3-Trifluoromethylphenyl)-1,2,4-triazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of 16.4 g of 2A and 17.6 g of 3-trifluoromethylphenylhydrazine were stirred and heated to 60° C. Dimethylamine was evolved in an exothermic reaction and the temperature maintained at 90° C. until evolution ceased (about 30 minutes). After cooling, the reaction mixture was dissolved in ether, washed with water, dried and chromatographically purified to yield 1-(3-trifluoromethylphenyl)-1,2,4-triazole (2B).

Aufarbeitung

  1. temperaturethe temperature maintained at 90° C. until evolution
  2. custom(about 30 minutes)
  3. temperatureAfter cooling
  4. washwashed with water
  5. customdried
  6. customchromatographically purified

Quellen und Nachweise

ORD-Eintrag
ord-a74c22ae80eb479b8eb7d28d9fcd5a11
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04610717

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