Hydrochloric Acid → 1-Phenyl-4-ethoxycarbonyl-5-chloro-1,2,3-triazole
Reaktionsgleichung
[C:1]1([N:7]2[C:11](O)=[C:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[N:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:19].Cl>>[C:1]1([N:7]2[C:11]([Cl:19])=[C:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[N:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1Komponenten
4
Reaktionsbedingungen
- Temperatur
- 70 °C
Versuchsvorschrift
11.65 g of 20A was mixed with 13.8 g of phosphorus pentachloride, and the mixture was slowly heated to ca. 70° C., when vigorous reaction occurred. When reaction had subsided, heating was continued until evolution of hydrogen chloride ceased (about 1 hour), after which phosphoryl chloride was removed in vacuo, and the residue chromatographically purified to yield 1-phenyl-4-ethoxycarbonyl-5-chloro-1,2,3-triazole (20B), as a solid, m.p.: 80°-81° C.