Water → 5-(2-Formyl-3-hydroxyphenoxy)pentanoic acid

HRID 647904

Reaktionsgleichung

Reaktionsgleichung von HRID 647904
[CH:1]([C:3]1[C:16]([OH:17])=[C:15](C(O)=O)[CH:14]=[CH:13][C:4]=1[O:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[O:2].O.[OH-].[Na+]>O1CCOCC1>[CH:1]([C:3]1[C:16]([OH:17])=[CH:15][CH:14]=[CH:13][C:4]=1[O:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[O:2]

Komponenten

5

Edukt 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 204843435-(2-Formyl-3-hydroxy-4-carboxyphenoxy)pentanoic acid

Produkt 1

HCID 721625-(2-Formyl-3-hydroxyphenoxy)pentanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

5-(2-Formyl-3-hydroxy-4-carboxyphenoxy)pentanoic acid (0.2 g, 0.0007 M), acidic alumina (0.1 g), water (10 ml) and dioxane (3 ml) were left at reflux for 4 days. The reaction mixture was cooled, and made alkaline by the addition of sodium hydroxide. The reaction mixture was filtered and the filtrate acidified with concentrated hydrochloric acid. The resulting precipitate was filtered and washed with a little water, then dried in a desiccator over phosphorus pentoxide to give the title compound as a pale-yellow solid, homogeneous on thin layer chromatography.

Aufarbeitung

  1. temperatureat reflux for 4 days
  2. temperatureThe reaction mixture was cooled
  3. filtrationThe reaction mixture was filtered
  4. filtrationThe resulting precipitate was filtered
  5. washwashed with a little water
  6. dry with materialdried in a desiccator over phosphorus pentoxide

Quellen und Nachweise

ORD-Eintrag
ord-83a0171f6a7a4a3a900cc9b5587a8149
Quelldatensatz
uspto-grants-1983_10
Patentnummer
US04410537

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