Methane → 6-Ethyl-5-propanoylpyridin-2(1H)-one

HRID 648380Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 648380
[CH2:1]([C:3]1[NH:4][C:5](=[O:16])[C:6](=[CH:10][C:11]=1[C:12](=[O:15])[CH2:13][CH3:14])C(O)=O)[CH3:2].C>C(O)C>[CH2:1]([C:3]1[NH:4][C:5](=[O:16])[CH:6]=[CH:10][C:11]=1[C:12](=[O:15])[CH2:13][CH3:14])[CH3:2]

Komponenten

4

Edukt 2

HCID 297MethaneHCID 132365116-Ethyl-2-oxo-5-propanoyl-1,2-dihydropyridine-3-carboxylic acid

Produkt 1

HCID 132365086-Ethyl-5-propanoylpyridin-2(1H)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A 15 g portion of 6-ethyl-1,2-dihydro-2-oxo-5-(n-propanoyl)-nicotinic acid was heated in an oil bath at 235°-240° C. for 5 hours, cooled and the reaction mixture dissolved in hot ethanol, treated with decolorizing charcoal and filtered. The filtrate was evaporated in dryness and the residue recrystallized from isopropyl alcohol to yield 8.2 g of 6-ethyl-5-(n-propanoyl)-2(1H)-pyridinone, m.p. 138°-140° C.

Aufarbeitung

  1. temperaturecooled
  2. filtrationfiltered
  3. customThe filtrate was evaporated in dryness
  4. customthe residue recrystallized from isopropyl alcohol

Quellen und Nachweise

ORD-Eintrag
ord-54804d8e4dd445e885a2f4a043888047
Quelldatensatz
uspto-grants-1983_10
Patentnummer
US04412077

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