Water → 4-Benzyloxyphenylacetonitrile

HRID 648383

Reaktionsgleichung

Reaktionsgleichung von HRID 648383
O.[C-:2]#[N:3].[Na+].[CH2:5]([O:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17]Cl)=[CH:15][CH:14]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>[Cl-].C([N+](CC)(CC)CC1C=CC=CC=1)C.C1C=CC=CC=1>[CH2:5]([O:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17][C:2]#[N:3])=[CH:15][CH:14]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Komponenten

6

Edukt 3

HCID 962WaterHCID 8929Sodium CyanideHCID 700424-Benzyloxybenzyl chloride

Produkt 1

HCID 5228044-BenzyloxyphenylacetonitrileAusbeute 95,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 66133Benzyl triethylammonium chlorideKatalysatorHCID 241BenzeneLösungsmittel

Versuchsvorschrift

In a 100 ml four-necked flask, there were placed 3.2 g of water, 1.23 g (0.025 mole) of sodium cyanide and 0.16 g of triethylbenzylammonium chloride, and a solution prepared by dissolving 5.3 g (0.023 mole) of 4-benzyloxybenzyl chloride in 6 g of benzene was further added thereto under stirring. Then, the resultant mixture was heated at a temperature of 80° C. for 5 hours under stirring to permit a reaction. After completion of the reaction, the formed organic layer is washed with water and dried over anhydrous sodium sulfate, followed by distilling off benzene to obtain 4.83 g (0.022 mole) of 4-benzyloxyphenylacetonitrile.

Aufarbeitung

  1. customIn a 100 ml four-necked flask, there were placed
  2. additionwas further added
  3. stirringunder stirring
  4. customa reaction
  5. customAfter completion of the reaction
  6. washthe formed organic layer is washed with water
  7. dry with materialdried over anhydrous sodium sulfate
  8. distillationby distilling off benzene

Quellen und Nachweise

ORD-Eintrag
ord-bc8b17a29a6a467894d09da987b7a9d3
Quelldatensatz
uspto-grants-1983_10
Patentnummer
US04412082

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