Methyl Acrylate → Methyl 3-(phenylthio)propionate

HRID 648624Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 648624
[C:1]1([SH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CCN(CC)CC.[C:15]([O:19][CH3:20])(=[O:18])[CH:16]=[CH2:17]>C(Cl)Cl>[C:1]1([S:7][CH2:17][CH2:16][C:15]([O:19][CH3:20])=[O:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 7294Methyl AcrylateHCID 7969ThiophenolHCID 8471Triethylamine

Produkt 1

HCID 350367Methyl 3-(phenylthio)propionate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Thiophenol (440 mg, 4 mmol) and Et3N (70 μl, 0.5 mmol) were dissolved in CH2Cl2 (5 ml). Methyl acrylate (412 mg, 4.8 mmol) was added dropwise. The reaction was exothermic. After stirring at room temperature for 30 minutes, the excess methyl acrylate was removed in vacuo. TLC: silica gel, Et2O-hexane 1:2, UV Rf =0.58. The crude title ester was used without further purification.

Aufarbeitung

  1. customthe excess methyl acrylate was removed in vacuo
  2. customThe crude title ester was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-49eb8f9cfeef495d87447e5574807b06
Quelldatensatz
uspto-grants-1988_04
Patentnummer
US04735962

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