HCID 20145212, Verbindung → HCID 20145176, Verbindung

HRID 648657Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 648657
Cl[C:2]1[CH:3]=[CH:4][C:5]([N:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)=[C:6]([CH:8]([CH:12]([C:22]([NH2:24])=[O:23])[C:13]2[CH:21]=[CH:20][C:16]([C:17]([OH:19])=[O:18])=[CH:15][CH:14]=2)[CH2:9][CH2:10][CH3:11])[CH:7]=1.[H][H]>C(O)C.[Pd]>[N:25]1([C:5]2[CH:4]=[CH:3][CH:2]=[CH:7][C:6]=2[CH:8]([CH:12]([C:22]([NH2:24])=[O:23])[C:13]2[CH:21]=[CH:20][C:16]([C:17]([OH:19])=[O:18])=[CH:15][CH:14]=2)[CH2:9][CH2:10][CH3:11])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]1

Komponenten

5

Edukt 2

HCID 20145212HCID 20145212, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 20145176HCID 20145176, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

One gram (2.33 m mol) of 4-[(1-(5-chloro-2-piperidinophenyl)-1-butyl)-aminocarbonylmethyl]-benzoic acid in 40 ml of absolute ethanol was hydrogenated on 0.5 gm of 10% palladium/charcoal at 50° C. and under 5 bar of hydrogen. After two hours, the catalyst was filtered off over kieselguhr, and the filtrate was concentrated by evaporation in vacuo. The evaporation residue was distributed at pH 6 between water and ethyl acetate. The organic extract was washed with water, dried, filtered, and evaporated in vacuo.

Aufarbeitung

  1. filtrationthe catalyst was filtered off over kieselguhr
  2. concentrationthe filtrate was concentrated by evaporation in vacuo
  3. extractionThe organic extract
  4. washwas washed with water
  5. customdried
  6. filtrationfiltered
  7. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-520e625b59054f978c9441a6f29369ca
Quelldatensatz
uspto-grants-1988_04
Patentnummer
US04735959

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