Sodium metaborate → 1-(4-Allyloxyphenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanol

HRID 64898

Reaktionsgleichung

Reaktionsgleichung von HRID 64898
B([O-])=O.[Na+].[CH2:5]([O:8][C:9]1[CH:27]=[CH:26][C:12]([O:13][CH:14]([N:21]2[CH:25]=[N:24][CH:23]=[N:22]2)[C:15](=[O:20])[C:16]([CH3:19])([CH3:18])[CH3:17])=[CH:11][CH:10]=1)[CH:6]=[CH2:7]>CO>[CH2:5]([O:8][C:9]1[CH:10]=[CH:11][C:12]([O:13][CH:14]([N:21]2[CH:25]=[N:24][CH:23]=[N:22]2)[CH:15]([OH:20])[C:16]([CH3:19])([CH3:18])[CH3:17])=[CH:26][CH:27]=1)[CH:6]=[CH2:7]

Komponenten

4

Edukt 2

HCID 145326Sodium metaborateHCID 133686231-(4-Allyloxyphenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanone

Produkt 1

HCID 133686241-(4-Allyloxyphenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanolAusbeute 97,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

1 g (0.027 mole) of sodium boranate is added in portions to 7.2 g (0.023 mole) of 1-(4-allyloxyphenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanone (Example 1) in 80 ml of methanol at 20° C., while stirring. The mixture is subsequently stirred for 1 hour and is then concentrated in vacuo by distilling off the solvent. The residue is partitioned between methylene chloride and water. The organic phase is separated off, dried over sodium sulphate and concentrated in vacuo. 7 g (97.2% of theory) of 1-(4-allyloxyphenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanol of melting point 85° C. are obtained.

Aufarbeitung

  1. stirringThe mixture is subsequently stirred for 1 hour
  2. concentrationis then concentrated in vacuo
  3. distillationby distilling off the solvent
  4. customThe residue is partitioned between methylene chloride and water
  5. customThe organic phase is separated off
  6. dry with materialdried over sodium sulphate
  7. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-bf3ac941a9f04771a1236503f1887025
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04610996

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