Tetrahydrofuran → HCID 20144491, Verbindung

HRID 649017Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 649017
Br[C:2](Br)=[CH:3][C:4]1[C:5]2[CH:12]=[CH:11][CH:10]=[C:9]([CH3:13])[C:6]=2[S:7][CH:8]=1.O1CCCC1.C([Li])CCC.C([O-])(O)=O.[Na+]>CCCCCC>[C:3]([C:4]1[C:5]2[CH:12]=[CH:11][CH:10]=[C:9]([CH3:13])[C:6]=2[S:7][CH:8]=1)#[CH:2]

Komponenten

6

Edukt 4

HCID 8028TetrahydrofuranHCID 516892Sodium BicarbonateHCID 20144461HCID 20144461, VerbindungHCID 178418339Butyllithium

Produkt 1

HCID 20144491HCID 20144491, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8058HexaneLösungsmittel

Versuchsvorschrift

0.6 g of 3-(dibromovinyl)-7-methylbenzo[b]thiophene are dissolved in abs. tetrahydrofuran and 3.38 ml of a 15% solution of n-butyllithium in n-hexane are added dropwise under inert gas and at -78°. Stirring is continued for one hour at -78° and the mixture subsequently warmed to room temperature, poured into saturated aq. NaHCO3 and extracted with ether. The organic phase is washed, dried, concentrated and directly further reacted.

Aufarbeitung

  1. extractionextracted with ether
  2. washThe organic phase is washed
  3. customdried
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-0eb66eba03164279873631165f2d56a4
Quelldatensatz
uspto-grants-1988_04
Patentnummer
US04737516

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