Water → 4-allyloxy-3-methyl-5,6,7,8-tetrahydroquinoline-N-oxide

HRID 649170Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 649170
[CH3:1][C:2]1[CH:3]=[N+:4]([O-:15])[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=2[C:11]=1[N+]([O-])=O.[OH-].[Na+].O.[CH2:19]([OH:22])[CH:20]=[CH2:21]>>[CH2:19]([O:22][C:11]1[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[N+:4]([O-:15])=[CH:3][C:2]=1[CH3:1])[CH:20]=[CH2:21]

Komponenten

5

Edukt 4

HCID 962WaterHCID 7858Allyl AlcoholHCID 14798Sodium HydroxideHCID 139602613-methyl-4-nitro-5,6,7,8-tetrahydroquinoline-N-oxide

Produkt 1

HCID 141555204-allyloxy-3-methyl-5,6,7,8-tetrahydroquinoline-N-oxide

Versuchsvorschrift

2.0 Grams of 3-methyl-4-nitro-5,6,7,8-tetrahydroquinoline-N-oxide was dissolved in allyl alcohol. Then 0.6 g of sodium hydroxide was added thereto, and the mixture was stirred at 70°-80° C. for 3 hours. After the reaction was completed, the reaction mixture was concentrated under reduced pressure, to the residue thus obtained was added water, and was extracted with chloroform. The chloroform layer was washed with an aqueous solution saturated with sodium chloride, then dried with anhydrous magnesium sulfate. Chloroform was removed by evaporation under reduced pressure to obtain 1.4 g of 4-allyloxy-3-methyl-5,6,7,8-tetrahydroquinoline-N-oxide in the form of brown oily substance.

Aufarbeitung

  1. concentrationthe reaction mixture was concentrated under reduced pressure, to the residue
  2. customthus obtained
  3. extractionwas extracted with chloroform
  4. washThe chloroform layer was washed with an aqueous solution saturated with sodium chloride
  5. dry with materialdried with anhydrous magnesium sulfate
  6. customChloroform was removed by evaporation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b996dfc1b23e4740bdd6961c6e3ae78d
Quelldatensatz
uspto-grants-1988_04
Patentnummer
US04738970

Notizen zur Reaktion

Wird geladen…