Methanethiol → HCID 14809494, Verbindung

HRID 649311Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 649311
Cl[C:2]1([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:15]=2[OH:22])[C:7](=[O:8])[N:6]([CH3:9])[C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[S:3]1.[CH3:23][SH:24]>O1CCCC1>[OH:22][C:15]1[CH:16]=[CH:17][C:18]([O:20][CH3:21])=[CH:19][C:14]=1[C:2]1([S:24][CH3:23])[C:7](=[O:8])[N:6]([CH3:9])[C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[S:3]1

Komponenten

4

Edukt 2

HCID 878MethanethiolHCID 14809492HCID 14809492, Verbindung

Produkt 1

HCID 14809494HCID 14809494, VerbindungAusbeute 78,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

2-Chloro-3,4-dihydro-2-(2-hydroxy-5-methoxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine (12.3 g, compound No. 3) is added to a mixture of 30% aqueous methyl mercaptan solution (26 ml) and tetrahydrofuran (50 ml). The mixture is stirred for 1.5 hours at room temperature and concentrated in vacuo. The separated crystals are collected by filtration to give 10.0 g (78.3%) of the titled compound.

Aufarbeitung

  1. concentrationconcentrated in vacuo
  2. filtrationThe separated crystals are collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-e7ac83adb3084309bbc6d48504431d6f
Quelldatensatz
uspto-grants-1988_04
Patentnummer
US04739050

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