Benzo(B)Thiophene → 2,3-Dihydrobenzo(b)thiophene

HRID 64951

Reaktionsgleichung

Reaktionsgleichung von HRID 64951
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1>O.[Na].[Hg]>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH2:3][CH2:2]1

Komponenten

4

Edukt 1

HCID 7221Benzo(B)Thiophene

Produkt 1

HCID 783192,3-Dihydrobenzo(b)thiophene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9837419Sodium amalgamKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

The dihydrobenzothiophenes are prepared as depicted in Chart D. A solution of a formula LX benzothiophene in water is stirred with excess sodium amalgam (NaHg) for 24 hr. After workup there is obtained the corresponding Formula LXI dihydrobenzothiophene. (See, e.g., D. T. Witiak, et al., J. Med. Chem. 14, 754 (1971).)

Quellen und Nachweise

ORD-Eintrag
ord-b72bcf250541411db5b39c9ed0780759
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04611059

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