1,2-Dichloroethane → 2-acetylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one

HRID 650002Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 650002
[S:1]1[C:5]2[O:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[NH:9][C:10](=[O:11])[C:4]=2[CH:3]=[CH:2]1.ClCCCl.[C:20](Cl)(=[O:22])[CH3:21].[Cl-].[Al+3].[Cl-].[Cl-]>C(Cl)(Cl)Cl>[C:20]([C:2]1[S:1][C:5]2[O:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[NH:9][C:10](=[O:11])[C:4]=2[CH:3]=1)(=[O:22])[CH3:21]

Komponenten

6

Edukt 4

HCID 111,2-DichloroethaneHCID 6367Acetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 18422172Thieno[2,3-b][1,5]benzoxazepin-4(5H)-one

Produkt 1

HCID 184223372-acetylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Thieno[2,3-b][1,5]benzoxazepin-4(5H)-one (5 g) was suspended to 1,2-dichloroethane (50 ml) and acetyl chloride was added (2.2 g). To this reaction system was added portionwise aluminum chloride (15 g) under ice-cooling and the mixture was stirred at room temperature for 10 minutes. The reaction system was poured into ice. Chloroform was added and the mixture was stirred for 15 minutes. The precipitated crystals were collected by filtration to give 2-acetylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one (5.2 g).

Aufarbeitung

  1. additionwas added (2.2 g)
  2. temperaturecooling
  3. additionThe reaction system was poured into ice
  4. stirringthe mixture was stirred for 15 minutes
  5. filtrationThe precipitated crystals were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-8a9a0fab71fd41de85f86f46ccd60960
Quelldatensatz
uspto-grants-2001_08
Patentnummer
US06271225B1

Notizen zur Reaktion

Wird geladen…