Acetic acid, 2-(4-formylphenoxy)- → Pyrimidin-2,4-dione, 6-amino-5-[(4-carboxymethoxy)benzimidoyl]-1,3-dipr

HRID 65002

Reaktionsgleichung

Reaktionsgleichung von HRID 65002
[C:1]([CH2:4][O:5][C:6]1[CH:13]=[CH:12][C:9]([CH:10]=O)=[CH:8][CH:7]=1)([OH:3])=[O:2].[NH2:14][C:15]1[C:16](=[O:29])[N:17]([CH2:26][CH2:27][CH3:28])[C:18](=[O:25])[N:19]([CH2:22][CH2:23][CH3:24])[C:20]=1[NH2:21]>CO.C(O)(=O)C>[NH2:21][C:20]1[N:19]([CH2:22][CH2:23][CH3:24])[C:18](=[O:25])[N:17]([CH2:26][CH2:27][CH3:28])[C:16](=[O:29])[C:15]=1[N:14]=[CH:10][C:9]1[CH:12]=[CH:13][C:6]([O:5][CH2:4][C:1]([OH:3])=[O:2])=[CH:7][CH:8]=1

Komponenten

5

Edukt 2

HCID 89177Acetic acid, 2-(4-formylphenoxy)-HCID 50986055,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedione

Produkt 1

HCID 614654Pyrimidin-2,4-dione, 6-amino-5-[(4-carboxymethoxy)benzimidoyl]-1,3-dipr

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

A representative synthesis of benzylidene adduct is given. Compound A (1.51 g, 8.37 mmol) was dissolved in a mixture of methanol (35 ml) and acetic acid (5 ml) in a 50 ml boiling flask on a steam bath. To this was added a methanolic solution (60 ml) of freshly synthesized 5,6-diamino-1,3-dipropyluracil. After heating 15 minutes, the volume was reduced by evaporation until crystallization occurred. Ether (40 ml) was added and the nearly white solid was collected. Yield 2.80 g (86%), mp 179°-180° C. Analysis (C19H24N4O5): calc. 58.60% C, 6.21% H, 14.39% N; found 58.72% C, 6.16% H, 14.43% N.

Aufarbeitung

  1. customA representative synthesis of benzylidene adduct
  2. temperatureAfter heating 15 minutes
  3. customthe volume was reduced by evaporation until crystallization
  4. additionEther (40 ml) was added
  5. customthe nearly white solid was collected

Quellen und Nachweise

ORD-Eintrag
ord-a7d385ad8eba4da9bf9d492fd1a5c7a1
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04612315

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