Water → 5-Methyloctahydro-1H-4,7-methanoinden-5-ol

HRID 650297

Reaktionsgleichung

Reaktionsgleichung von HRID 650297
[CH:1]12[CH2:11][CH:7]([C:8](=[O:10])[CH2:9]1)[CH:6]1[CH:2]2[CH2:3][CH2:4][CH2:5]1.[CH3:12][Mg]Cl.O>O1CCCC1>[CH3:12][C:8]1([OH:10])[CH2:9][CH:1]2[CH2:11][CH:7]1[CH:6]1[CH:2]2[CH2:3][CH2:4][CH2:5]1

Komponenten

5

Edukt 3

HCID 962Water2×HCID 965094,7-Methano-5H-inden-5-one, octahydro-HCID 178418332HCID 178418332, Verbindung

Produkt 1

HCID 134625055-Methyloctahydro-1H-4,7-methanoinden-5-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel3×

Versuchsvorschrift

Tricyclo [5.2.1.02,6] decan-8-one (15.0 g) in tetrahydrofuran (THF, 50 ml) is slowly added into CH3MgCl (9.7 g) in THF and the reaction mixture is stirred completely. Tetrahydrofuran (THF, 100 ml) with 5% of water is added into the reaction mixture. Then 100 ml of water is added to the reaction mixture. The reaction mixture is extracted by ether. The organic extract is concentrated in vacuo to yield 8-methyl-tricyclo [5.2.1.02,6] decan-8-ol (formula (X)) as white solid.

Aufarbeitung

  1. extractionThe reaction mixture is extracted by ether
  2. extractionThe organic extract
  3. concentrationis concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ad544c725db040258fa7900dde80a2eb
Quelldatensatz
uspto-grants-2001_08
Patentnummer
US06271412B1

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