Hydrogen Bromide → 3-(5-Chloro-3-fluoropyridin-2-yl)-2-methyl-3-oxopropionic acid
Reaktionsgleichung
C([O:5][C:6](=[O:19])[CH:7]([CH3:18])[C:8]([C:10]1[C:15]([F:16])=[CH:14][C:13]([Cl:17])=[CH:12][N:11]=1)=[O:9])(C)(C)C.Br>C(O)(=O)C>[Cl:17][C:13]1[CH:14]=[C:15]([F:16])[C:10]([C:8](=[O:9])[CH:7]([CH3:18])[C:6]([OH:19])=[O:5])=[N:11][CH:12]=1Komponenten
4
Versuchsvorschrift
25.5 g of 3- (5-chloro-3-fluoropyridin-2-yl)-2-methyl-3-oxopropionic acid tert-but yl ester (Example P34) are added dropwise to 30 ml of a 33% solution of hydrogen bromide (HBr) in glacial acetic acid to form a suspension. The mixture is subsequently stirred for 90 minutes and then introduced into 300 ml of ice-water. The resulting precipitate is filtered off, washed with water and dried. 15.9 g of the desired title compound are obtained in the form of a solid having a melting point of 101-102° C.