Potassium Carbonate → 9-(1,3-Di-n-octanoyloxy-2-propoxymethyl)guanine

HRID 65110

Reaktionsgleichung

Reaktionsgleichung von HRID 65110
Cl.[C:2]([O:11][CH2:12][CH:13]([O:25][CH2:26][N:27]1[CH:35]=[N:34][C:33]2[C:32](=[O:36])[NH:31][C:30]([NH2:37])=[N:29][C:28]1=2)[CH2:14][O:15][C:16](=[O:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])(=[O:10])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].C(=O)([O-])[O-].[K+].[K+]>CCOCC>[C:2]([O:11][CH2:12][CH:13]([O:25][CH2:26][N:27]1[CH:35]=[N:34][C:33]2[C:32](=[O:36])[NH:31][C:30]([NH2:37])=[N:29][C:28]1=2)[CH2:14][O:15][C:16](=[O:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])(=[O:10])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 136332160HCID 136332160, Verbindung

Produkt 1

HCID 1363321599-(1,3-Di-n-octanoyloxy-2-propoxymethyl)guanine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

1.0 g of 9-(1,3-di-n-octanoyloxy-2 propoxymethyl)guanine HCl suspended in 50 ml of ether is stirred with a twofold stoichiometric excess of dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over maganesium sulfate and evaporated to yield 9-(1,3-di-n-octanoyloxy-2-propoxy methyl)guanine as the free base.

Aufarbeitung

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over maganesium sulfate
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-06d9d6e24aa64ee1a180e02e8359c70e
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04612314

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