Oxalyl chloride → 3-Cyano-2,4,5-trifluoro-benzoyl chloride

HRID 651287Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 651287
[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6](O)=[O:7])#[N:2].C(Cl)(=O)C([Cl:18])=O>CN(C)C=O.C(Cl)Cl>[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6]([Cl:18])=[O:7])#[N:2]

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 18417533195532-64-0

Produkt 1

HCID 186187613-Cyano-2,4,5-trifluoro-benzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

111 g of 3-cyano-2,4,5-trifluoro-benzoic acid, 84 g of oxalyl chloride and a few drops of dimethylformamide in 930 ml of dry methylene chloride are stirred at room temperature for 5 hours. The reaction mixture is concentrated by evaporation and the residue is distilled in vacuo.

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated by evaporation
  2. distillationthe residue is distilled in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1abbf27288ca486b9d54f2bbfd337b1c
Quelldatensatz
uspto-grants-2001_08
Patentnummer
US06278013B1

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