Mandelic Acid → Sotalol

HRID 651495

Reaktionsgleichung

Reaktionsgleichung von HRID 651495
[CH3:1][CH:2]([NH:4][CH2:5][C@@H:6]([OH:18])[C:7]1[CH:12]=[CH:11][C:10]([NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][CH:8]=1)[CH3:3].Cl.C(O)(=O)C(C1C=CC=CC=1)O>>[CH3:3][CH:2]([NH:4][CH2:5][CH:6]([OH:18])[C:7]1[CH:8]=[CH:9][C:10]([NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:11][CH:12]=1)[CH3:1]

Komponenten

3

Edukt 2

HCID 1292Mandelic AcidHCID 165245Dexsotalol Hydrochloride

Produkt 1

HCID 5253Sotalol

Versuchsvorschrift

In addition, using chemical method as described by Le Garrec (1987), enriched d-sotalol hydrochloride and l-sotalol hydrochloride were prepared using mandelic acid and subjected to conversion to the base form, chiral separation and reconversion to hydrochloride salt was carried out. The details of these procedures are given below:

Aufarbeitung

  1. customwere prepared
  2. customsubjected to conversion to the base form, chiral separation and reconversion to hydrochloride salt

Quellen und Nachweise

ORD-Eintrag
ord-b1da450602074d29b7a1aa7f0ca08711
Quelldatensatz
uspto-grants-2001_08
Patentnummer
US06281246B1

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