1-Methyl-6-nitro-1H-indole → 1-methyl-1H-indol-6-amine
Reaktionsgleichung
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([N+:11]([O-])=O)[CH:9]=2)[CH:4]=[CH:3]1>C(O)C.O1CCCC1.[Pd]>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH2:11])[CH:9]=2)[CH:4]=[CH:3]1Komponenten
5
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
A mixture of 1-methyl-6-nitro-1H-indole (5.0 g, 28.4 mmol) and 10% Pd/C(1.0 g) in ethanol (200 ml) and tetrahydrofuran (100 ml) was hydrogenated at atmospheric pressure for 14 hours. The reaction mixture was filtered and concentrated to give 1-methyl-6-amino-1H-indole after crystallization from ether/hexane (3.8 g, 80%).
Aufarbeitung
- filtrationThe reaction mixture was filtered
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-43114244a0d84dc88471a1748567d7c5
- Quelldatensatz
- uspto-grants-2001_08
- Patentnummer
- US06281356B1
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