Dichloromethane → HCID 20198267, Verbindung

HRID 652028

Reaktionsgleichung

Reaktionsgleichung von HRID 652028
Cl.[CH3:2][Si:3]([CH3:29])([CH3:28])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1.C(Cl)Cl.[OH:33][CH:34]([CH2:39][CH3:40])[C:35]([O:37][CH3:38])=[O:36].C(N(CC)CC)C>CCOCC>[CH3:2][Si:3]([CH3:29])([CH3:28])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([O:33][CH:34]([C:35]([O:37][CH3:38])=[O:36])[CH2:39][CH3:40])=[O:24])=[CH:21][CH:20]=1

Komponenten

6

Edukt 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 520445Methyl 2-hydroxybutanoateHCID 20198230HCID 20198230, Verbindung

Produkt 1

HCID 20198267HCID 20198267, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a solution of 10.0 g. 4-[14-(trimethylsilyl)tetradecylamino]benzoyl chloride hydrochloride in 200 ml. methylene chloride is added dropwise a solution of 3 g. methyl α-hydroxybutyrate and 5 g. triethylamine in 100 ml. ether. After 17 hours stirring at room temperature, the precipitate is collected and washed with several portions of ether. The ether solution is washed with water, dried and evaporated to yield the product as a white solid.

Aufarbeitung

  1. customthe precipitate is collected
  2. washwashed with several portions of ether
  3. washThe ether solution is washed with water
  4. customdried
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-703c8991bd5548c08ffbd47fb47e00ab
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04670421

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