Hydrochloric Acid → Levamisole

HRID 652553

Reaktionsgleichung

Reaktionsgleichung von HRID 652553
[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]2[N:14]=[C:13]3[N:9]([CH2:10][CH2:11][S:12]3)[CH2:8]2)=[CH:5][CH:6]=1.Cl.Cl.[OH-].[Na+]>O>[CH:1]1[CH:6]=[CH:5][C:4]([C@@H:7]2[N:14]=[C:13]3[N:9]([CH2:10][CH2:11][S:12]3)[CH2:8]2)=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68628Tetramisole hydrochloride

Produkt 1

HCID 26879LevamisoleAusbeute 115,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

To a warmed solution, 40° C., of 24.08 g of tetramisole hydrochloride (0.1 mol) in 113 ml. water adjusted to pH 4 with hydrochloric acid was added dropwise during a period of 50 minutes a suspension containing 15.85 g of L-N-[(4-methoxyphenyl)sulfonyl]glutamic acid (0.05 mol) and 2 g of sodium hydroxide (0.05 mol) in 85 ml of water. The mixture was cooled to 15°-20° C. and additionally stirred during 5 hours. The precipitate was filtered off, washed with water and dried under vacuo at 50° C., yielding 23.55 g of levamisole.L-N-[(4-methoxyphenyl)sulfonyl]glutamic acid (salt) (yield=90.3%); αD20 =-63° (c5, 1N HCl); mp. 127.4°-128.1° C.

Aufarbeitung

  1. customTo a warmed solution, 40° C.
  2. additionwas added dropwise during a period of 50 minutes a suspension
  3. temperatureThe mixture was cooled to 15°-20° C.
  4. filtrationThe precipitate was filtered off
  5. washwashed with water
  6. customdried under vacuo at 50° C.

Quellen und Nachweise

ORD-Eintrag
ord-f52767d35d5a4894acefba9be7a5658b
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04672126

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