Hydrochloric Acid → Levamisole

HRID 652554

Reaktionsgleichung

Reaktionsgleichung von HRID 652554
[OH-].[Na+].[CH:3]1[CH:4]=[CH:5][C:6]([CH:9]2[N:16]=[C:15]3[N:11]([CH2:12][CH2:13][S:14]3)[CH2:10]2)=[CH:7][CH:8]=1.Cl.Cl>O>[CH:3]1[CH:8]=[CH:7][C:6]([C@@H:9]2[N:16]=[C:15]3[N:11]([CH2:12][CH2:13][S:14]3)[CH2:10]2)=[CH:5][CH:4]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68628Tetramisole Hydrochloride

Produkt 1

HCID 26879LevamisoleAusbeute 124,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
15 °C

Versuchsvorschrift

A mixture containing 82.5 g of L-N-[(4-methoxyphenyl)sulfonyl]glutamic acid (0.26 mol), 445 ml of water, 27.3 ml. sodium hydroxide 19.5 molar aqueous solution (0.53 mol) and 120.38 g of tetramisole hydrochloride (0.5 mol) was warmed up to 40° C. The warmed homogeneous mixture was adjusted to pH 4.2 with hydrochloric acid and cooled at 15° C. After 16 hours the precipitate was filtered off, washed and dried under vacuo at 50° C., yielding 127.44 g of levamisole.L-N-[(4-methoxyphenyl)sulfonyl]glutamic acid (salt) (yield=97.7%) αD20 =-63.7° (c5, 1N HCl); mp. 127.5°-128.3° C.

Aufarbeitung

  1. filtrationAfter 16 hours the precipitate was filtered off
  2. washwashed
  3. customdried under vacuo at 50° C.

Quellen und Nachweise

ORD-Eintrag
ord-29a9303b28804d9f994d443da841763d
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04672126

Verknüpfte Notizen

Wird geladen…