Hydrochloric Acid → Levamisole

HRID 652555

Reaktionsgleichung

Reaktionsgleichung von HRID 652555
[OH-].[Na+].[CH:3]1[CH:4]=[CH:5][C:6]([CH:9]2[N:16]=[C:15]3[N:11]([CH2:12][CH2:13][S:14]3)[CH2:10]2)=[CH:7][CH:8]=1.Cl.Cl>O>[CH:3]1[CH:8]=[CH:7][C:6]([C@@H:9]2[N:16]=[C:15]3[N:11]([CH2:12][CH2:13][S:14]3)[CH2:10]2)=[CH:5][CH:4]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68628Tetramisole hydrochloride

Produkt 1

HCID 26879LevamisoleAusbeute 121,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

A mixture containing 11.39 kg of L-N-[(4-methoxyphenyl)sulfonyl]glutamic acid (35.9 mol), 61 l of water, 3.77 l sodium hydroxide 19.5 molar aqueous solution (73.5 mol) and 16.61 kg of tetramisole hydrochloride (69 mol) was warmed up to 40° C. The homogeneous mixture was adjusted to pH 4.2 with hydrochloric acid and cooled at 15° C. After 18 hours the precipitate was filtered off, washed and dried under vacuo at 50° C., yielding 17.15 kg of levamisole.L-N-[(4-methoxyphenyl)sulfonyl]glutamic acid (salt) (yield: 95%); αD20 =65.1° (c5, 1N HCl); mp. 127.9°-129.4° C.

Aufarbeitung

  1. temperaturecooled at 15° C
  2. filtrationAfter 18 hours the precipitate was filtered off
  3. washwashed
  4. customdried under vacuo at 50° C.

Quellen und Nachweise

ORD-Eintrag
ord-d6ac48afc5374a53b505ff34ed545656
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04672126

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