Ethyl Acetate → L-Phenylalanine

HRID 65321

Reaktionsgleichung

Reaktionsgleichung von HRID 65321
C[O:2][C:3](=[O:13])[CH:4]([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[NH2:5].C(OCC)(=O)C.[OH-].[Na+]>O>[NH2:5][C@H:4]([C:3]([OH:13])=[O:2])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Komponenten

5

Edukt 3

HCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 75737DL-Phenylalanine, methyl ester

Produkt 1

HCID 6140L-PhenylalanineAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 1.15 grams of D,L-phenylalanine methyl ester in 2.5 milliliters of water was added to 5.0 milliliters of ethyl acetate. The pH was adjusted to 6.5 with 2.5 milliliters of sodium hydroxide. Two milligrams of chymotrypsin was added and the reaction was stirred gently at room temperature. A white precipitate appeared after 1.5 hours. The precipitate was isolated after 2 hours yielding 0.22 grams with an optical rotation equivalent to 98% pure L-phenylalanine.

Aufarbeitung

  1. additionTwo milligrams of chymotrypsin was added
  2. customThe precipitate was isolated after 2 hours

Quellen und Nachweise

ORD-Eintrag
ord-a1998eaeb8504d398dcc88c0ffe4372b
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04613691

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