Water → AD 1308

HRID 653404Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 653404
Cl[C:2]1[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH2:18]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)[CH3:19].O>C1(C)C=CC=CC=1>[CH2:18]([N:20]1[CH2:25][CH2:24][N:23]([C:2]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[CH2:22][CH2:21]1)[CH3:19]

Komponenten

5

Edukt 3

HCID 962WaterHCID 791961-EthylpiperazineHCID 23066872-Chloro-4-phenylquinoline

Produkt 1

HCID 175033AD 1308Ausbeute 86,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A solution of 2-chloro-4-phenylquinoline (2.0 g) and 1-ethylpiperazine (2.7 g) in toluene (15 ml) is heated under reflux for 10 hours. To the reaction mixture is added water and the resulting mixture is extracted with ethyl acetate. The extracts are dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue is chromatographed on silica gel (25 g) using chloroform as an eluent. Fractions containing the title compound are pooled and concentrated to give the title compound (2.3 g).

Aufarbeitung

  1. temperatureunder reflux for 10 hours
  2. extractionthe resulting mixture is extracted with ethyl acetate
  3. dry with materialThe extracts are dried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customThe residue is chromatographed on silica gel (25 g)
  6. additionFractions containing the title compound
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-fcdbce7b3243487a95c98c789e4f2d1d
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04677107

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