3-(2-Oxo-1,2,3,4-tetrahydroquinolin-3-yl)propanoic acid → HCID 13519806, Verbindung

HRID 653430Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 653430
[O:1]=[C:2]1[CH:11](CCC(O)=O)[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1>C(OC(=O)C)(=O)C>[CH2:10]1[C:9]2=[CH:8][CH:7]=[CH:6][C:5]3=[C:4]2[N:3]([C:2](=[O:1])[CH2:11][CH2:10]3)[C:2](=[O:1])[CH2:11]1

Komponenten

3

Edukt 1

HCID 162275833-(2-Oxo-1,2,3,4-tetrahydroquinolin-3-yl)propanoic acid

Produkt 1

HCID 13519806HCID 13519806, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7918Acetic AnhydrideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

1,2,3,4-Tetrahydro-2-oxo-3-quinolinepropanoic acid (2.1 g, 0.0096 mole) is dissolved in acetic anhydride (10 ml) and the solution is heated to 100° C. for one hour. Excess acetic anhydride is removed at reduced pressure and the residual anhydride is removed by addition of toluene and repeated concentration. The solid is recrystallized from ethyl acetate to yield pure 1,2,6,7-tetrahydro-3H,5H-benzo[ij]quinolizine-3,5-dione, mp 136°-140° C.

Aufarbeitung

  1. customExcess acetic anhydride is removed at reduced pressure
  2. customthe residual anhydride is removed by addition of toluene
  3. concentrationconcentration
  4. customThe solid is recrystallized from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-f519d34ee95c48e08da8237f2541d28e
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04677112

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