Nitric Acid → HCID 19792129, Verbindung

HRID 653708Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 653708
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:12][C:13](=[O:18])[CH2:14][CH2:15][CH2:16][CH3:17])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[N+:19]([O-])([OH:21])=[O:20]>C(OC(=O)C)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([N+:19]([O-:21])=[O:20])[C:5]([NH:12][C:13](=[O:18])[CH2:14][CH2:15][CH2:16][CH3:17])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8]

Komponenten

4

Edukt 2

HCID 944Nitric AcidHCID 19792116HCID 19792116, Verbindung

Produkt 1

HCID 19792129HCID 19792129, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7918Acetic AnhydrideLösungsmittel

Versuchsvorschrift

To a solution of methyl 5-chloro-2valerylaminobenzoate (13.4 g) in acetic anhydride (10 ml) was added dropwise, while stirring under ice-cooling, fuming nitric acid. The mixture was stirred for one hour at room temperature, then there was added ice water. The mixture was allowed to stand to give crystals Recrystallization from isopropyl ether afforded pale yellow crystals (9.5 g, 61%), m.p. 84°-85° C.

Aufarbeitung

  1. temperaturecooling
  2. stirringThe mixture was stirred for one hour at room temperature
  3. customto give
  4. customcrystals Recrystallization from isopropyl ether afforded pale yellow crystals (9.5 g, 61%), m.p. 84°-85° C.

Quellen und Nachweise

ORD-Eintrag
ord-e6bbd3bc90f64c7ab67bbc79daf35106
Quelldatensatz
uspto-grants-1992_07
Patentnummer
US05128356

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