Trifluoroacetic acid → HCID 131717450, Verbindung

HRID 653858Notizen

Reaktionsgleichung

NC1SN=C(/[C:7](=N/OCF)/[C:8]([NH:10][C@@H:11]2[C:32](=[O:33])[N:13]3[C:14]([C:29]([O-:31])=[O:30])=[C:15](/[CH:18]=[CH:19]/[CH2:20][N+:21]([CH2:25][C:26](=[O:28])[NH2:27])([CH2:23]C)[CH3:22])[CH2:16][S:17][C@H:12]23)=[O:9])N=1.[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41].[C:45]1(OC)[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1>>[F:38][C:39]([F:44])([F:43])[C:40]([O-:42])=[O:41].[C:45]1([CH2:7][C:8]([NH:10][C@@H:11]2[C:32](=[O:33])[N:13]3[C:14]([C:29]([OH:31])=[O:30])=[C:15](/[CH:18]=[CH:19]/[CH2:20][N+:21]([C@@H:25]([C:26](=[O:28])[NH2:27])[CH3:39])([CH3:22])[CH3:23])[CH2:16][S:17][C@H:12]23)=[O:9])[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=1

Komponenten

Edukt 3

HCID 6422Trifluoroacetic acid

HCID 7519Anisole

HCID 6536774Cefluprenam

Produkt 1

HCID 131717450HCID 131717450, Verbindung

Versuchsvorschrift

In a similar manner as in Example 5, the compound (34.5 g) of Example 14 was suspended in anisole (210 ml), followed by an addition of trifluoroacetic acid (230 ml) to obtain the target compound (25.9 g).

Quellen und Nachweise

ORD-Eintrag: ord-b1b3598b01e04618bd12feda8544a772
Quelldatensatz: uspto-grants-1992_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05128465

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