Acetic Anhydride → N-(hydroxymethyl)acetamide acetate

HRID 654131Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 654131
[C:1]([O:4]C(=O)C)(=[O:3])[CH3:2].[OH:8][CH2:9][NH:10][C:11](=[O:13])[CH3:12]>N1C=CC=CC=1>[C:1]([OH:4])(=[O:3])[CH3:2].[OH:8][CH2:9][NH:10][C:11](=[O:13])[CH3:12]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 69365Formicin

Produkt 1

HCID 86745977N-(hydroxymethyl)acetamide acetateAusbeute 900 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineKatalysator

Versuchsvorschrift

Acetic anhydride (25 g) and pyridine (10 drops) is added to N-(hydroxymethyl)acetamide (9 g, 0.1 mol). The reaction mixture is stirred overnight at room temperature, concentrated in vacuo and chased with xylene to give the title product as an oil (11.9 g, 0.9 mol) which is identified by 1HNMR spectral analysis.

Aufarbeitung

  1. concentrationconcentrated in vacuo and chased with xylene

Quellen und Nachweise

ORD-Eintrag
ord-7855edfd6e3d4795bd89ba4395522031
Quelldatensatz
uspto-grants-1992_07
Patentnummer
US05130328

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