Chloroform → trans-2-Benzamido-cyclohexanol

HRID 654141Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 654141
[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[OH:8].C(Cl)(Cl)Cl.C(=O)(O)[O-].[Na+].[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>O>[C:18]([NH:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[OH:8])(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Komponenten

6

Edukt 4

HCID 6212ChloroformHCID 7412Benzoyl chlorideHCID 516892Sodium BicarbonateHCID 735777(1R,2R)-2-Aminocyclohexanol

Produkt 1

HCID 11020385trans-2-Benzamido-cyclohexanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

(±)-trans-2-Aminocyclohexanol (241 gm) was combined with chloroform (2000 ml), water (2000 ml) and sodium bicarbonate (352 gm) and stirred. Benzoyl chloride (352 gm) was added dropwise to the stirred solution and stirring was continued for 1 hr. The product was filtered and washed with water. The white solid was dried at 80° C. to provide the product (mp 172°-173° C.).

Aufarbeitung

  1. stirringstirring
  2. filtrationThe product was filtered
  3. washwashed with water
  4. customThe white solid was dried at 80° C.

Quellen und Nachweise

ORD-Eintrag
ord-1e65e57980244259877bef49e9219abb
Quelldatensatz
uspto-grants-1992_07
Patentnummer
US05130330

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