Water → (E)-1-[3-(5-ethyl-4-hydroxy-3-methoxy-1-naphthyl)-1-oxo-2-propenyl]piperidine

HRID 654725Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 654725
[CH2:1]([C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[C:5]([O:25]COC)=[C:6]([O:23][CH3:24])[CH:7]=[C:8]2/[CH:13]=[CH:14]/[C:15]([N:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)=[O:16])[CH3:2].O>CC(C)=O.Cl>[CH2:1]([C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[C:5]([OH:25])=[C:6]([O:23][CH3:24])[CH:7]=[C:8]2/[CH:13]=[CH:14]/[C:15]([N:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]1)=[O:16])[CH3:2]

Komponenten

5

Edukt 2

HCID 962WaterHCID 14986472(E)-1-[3-(5-ethyl-3-methoxy-4-methoxymethoxy-1-naphthyl)-1-oxo-2-propenyl]piperidine

Produkt 1

HCID 14986482(E)-1-[3-(5-ethyl-4-hydroxy-3-methoxy-1-naphthyl)-1-oxo-2-propenyl]piperidineAusbeute 89,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180AcetoneLösungsmittelHCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

960 mg of (E)-1-[3-(5-ethyl-3-methoxy-4-methoxymethoxy-1-naphthyl)-1-oxo-2-propenyl]piperidine was dissolved in 50 ml of acetone, to which 1 ml of concentrated hydrochloric acid was gradually added at room temperature. After stirring at room temperature for 5 hours, the reaction mixture was slowly poured into water. The resultant crystals were collected by filtration, washed with water and dried to obtain 760 mg of the titled compound as yellow crystals.

Aufarbeitung

  1. additionwas gradually added at room temperature
  2. filtrationThe resultant crystals were collected by filtration
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-200c22ae025642af8d5de183c25aa9a8
Quelldatensatz
uspto-grants-1992_07
Patentnummer
US05134111

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