Methyl (3S,4R)-4-(benzylamino)-3-methylpiperidine-1-carboxylate → Methyl (3S,4R)-4-amino-3-methylpiperidine-1-carboxylate

HRID 655770Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 655770
C([NH:8][C@@H:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH3:18])=[O:16])[CH2:11][C@@H:10]1[CH3:19])C1C=CC=CC=1>CO.[H][H].[Pd]>[NH2:8][C@@H:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH3:18])=[O:16])[CH2:11][C@@H:10]1[CH3:19]

Komponenten

5

Edukt 1

HCID 58075022Methyl (3S,4R)-4-(benzylamino)-3-methylpiperidine-1-carboxylate

Produkt 1

HCID 58075083Methyl (3S,4R)-4-amino-3-methylpiperidine-1-carboxylateAusbeute 101,6 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittelHCID 178418361HCID 178418361, VerbindungLösungsmittel

Versuchsvorschrift

Methyl (3S,4R)-4-(benzylamino)-3-methylpiperidine-1-carboxylate (8.0 g, 0.02 mol) was dissolved in methanol (200 mL) and hydrogenated at room temperature, under 50 psi of hydrogen pressure, in the presence of palladium (2.5 g) on carbon for 2 h. The solution was then filtered and concentrated under reduced pressure to yield 3.5 g (92%) Methyl (3S,4R)-4-amino-3-methylpiperidine-1-carboxylate as liquid.

Aufarbeitung

  1. filtrationThe solution was then filtered
  2. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e25b30d485d84329aefc171162f2844d
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08071605B2

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